Medrie MacPhee was born in Canada and received a BFA from the Nova Scotia College of Art and Design

Her work has been exhibited at Michael Steinberg Fine Art, New York; ArtCore Gallery, Toronto; National Gallery of Canada, Ottawa; Keith Talent Gallery, London; Paolo Baldacci Gallery, New York; Baldacci-Daverio Gallery, New York;  Phillipe Daverio Gallery, New York; Stadtische Galerie Haus, Siegen, Germany; the Pari Nadimi Gallery, Toronto; Espace 502, Montreal; Linda Generaux Gallery, Toronto;  Mira Godard Gallery, Toronto; Charles H. Scott Gallery, Vancouver, B.C; 49th Parallel, New York; and the Concordia University Art Gallery, Montreal.

Her work has also been in more than 40 group exhibitions, including: Michael Steinberg Art, New York (2004); Plus Ultra, Williamsburg (2004); Collaborative Concepts, Beacon, New York (2004); ArtPoint, Miami Art Fair(2003); DUMBO (2003);  Edmonton Art Gallery (2003);  Winnipeg Art Gallery (2002); Art Gallery of Greater Victoria (2002); National Gallery of Canada (2001); Edmonton Art Gallery (2001); Joseph Helman Gallery, New York (2001); Pari Nadimi Gallery, Toronto (2001, 1999); Nicole Klagsburn Gallery, New York (1999); Campo, Antwerp Belgium (1999); Marcel Sitcoske Gallery, San Francisco (1998)  Nielsen Gallery, Boston (1997); Musée d' art contemporain de Montréal (1996); Paolo Baldacci Gallery, New York (1996, 1994, 1993); MIART, Italy, (1995); Katonah Museum, New York (1995); Power Plant, Toronto (1995) Phillipe Daverio Gallery, New York (1991).

The Charles H. Scott Gallery in Vancouver and the Art Gallery of the Saidye Bronfman Centre for the Arts, Montreal organized Flight in the Variable Zone, a solo traveling exhibition of MacPhee's work, which toured Canada in 1999/2000.

MacPhee is represented in various private and public collections in the U.S., Canada and Europe, including: the Metropolitan Museum of Art, New York; The National Gallery of Canada; the Art Gallery of Ontario; Musée d'art contemporain de Montréal; the Edmonton Art Gallery; the Art Gallery of Greater Victoria; the Confederation Center Art Gallery, Charlottetown; and the Nickle Arts Museum, Calgary.

MacPhee has taught at Columbia University, Cooper Union, Rhode Island School of Design, Sarah Lawrence College and is currently the Sherri Burt Hennessey Artist-In-Residence at Bard College in Annandale-on-Hudson, New York.